Voices @ Research: NMRC Research Training Fellowship Experience
Recipient of the 2017 National Medical Research Council (NMRC) Research Training Fellowship Award Dr Ng Kok Pin, Consultant, National Neuroscience Institute, recently completed a one year training fellowship at the McGill University Research Centre for Studies in Aging (MCSA), Montreal. Dr Ng’s main research focus is in PET imaging in neurocognitive diseases. During his training fellowship, he gained immense experience in image processing, image co-registration, image analysis, and the organization of huge datasets, such as the Alzheimer’s Disease Neuroimaging Initiative (ADNI).
Paying People to Lose Weight Really Works!
A 4-month research study involving 161 participants, led by Duke-NUS Medical School and Singapore General Hospital (SGH), has found that participants who were part of a rewards scheme had better weight loss results compared with participants in a regular weight loss programme. "The payoff in terms of health can be significant", said Dr Tham Kwang Wei, Director, Life Centre, and Senior Consultant, Dept of Endocrinology, SGH. "Even small amounts of weight loss, sustained over time, confer great health benefits and can help prevent chronic disease."
A Promising Future for Cellular Replacement Therapies in Neurodegenerative Diseases
In the third session of Research Grand Round, 1st prize winners of the SingHealth Duke-NUS Research Team Award, Professor Tan Eng King, Senior Consultant Neurologist and Research Director, National Neuroscience Institute, Singapore General Hospital (SGH) and Assistant Professor Je Hyunsoo, Shawn, Neuroscience and Behavioural Disorders (NDB) Programme, Duke-NUS Medical School, shed some insights and discoveries on the latest developments in neuroscience, in particular with relation to Parkinson’s Disease (PD) and autism. Presenting both laboratory and clinical research findings, Prof Tan and Asst Prof Shawn discussed their ongoing work and how they have looked at various ways of overcoming these challenges and limitations
Protect Kids From Severe Injuries
A research study involving more than 1,000 children from KK Women's and Children Hospital (KKH) and National University Hospital (NUH) found that seven in ten head injuries are sustained from a fall. Dr Chong Shu-Ling, Staff Physician, Dept of Emergency Medicine, KKH, shared that "the likelihood of a severe outcome increased by 1.4 times with every metre increase in the height of the fall". Besides falls, other head injuries were attributed to traffic accidents, sports, interpersonal violence and non-accidental trauma. Read about the study intended to help prevent severe head injuries among children.
The Gene Mutation that can Prevent Glaucoma
Glaucoma is the leading cause of irreversible blindness worldwide. In the largest study on glaucoma to date, a team of researchers led by Singapore Eye Research Institute (SERI) and A*STAR’s Genome Institute of Singapore (GIS) have discovered a rare gene mutation that can help prevent the disease. The international collaboration on Exfoliation Syndrome, a major form of glaucoma, comprised of 120,000 individuals from 36 countries across six continents. “While it was very challenging to coordinate the research with most of the work being done in Singapore, the findings are very exciting as it can lead to the development of new therapies for glaucoma”, Prof Aung Tin, Executive Director of SERI and Deputy Medical Director of Singapore National Eye Centre (SNEC).
Breakthrough in Fight Against Mutated p53 Gene
A recent breakthrough study has found a new way to detect mutant p53 selectively. Although known as the “guardian of the genome”, p53 can be mutated and lose its ability to prevent cancer formation. Led by Prof Kanaga Sabapathy, Head, Division of Cellular and Molecular Research, National Cancer Centre Singapore (NCCS) and Prof Sir David Lane, Director, p53 Laboratory, A*STAR, the study generated antibodies that are specific to each p53 mutant and tested them on patient samples. Prof Kanaga and Prof Sir David Lane presented their latest discovery at the 17th International p53 Workshop over the weekend.