Voices @ Research: Debunking the Myths of Research
Embarking on research can be an overwhelming feat for many in busy clinical practice. In the latest edition of Voices, Dr Elaine Chew, Consultant, Adolescent Medicine Service, Department of Paediatrics, KK Women's and Children's Hospital (KKH), reflects on her research journey. In her article, she pens her motivations that led to research; some of the common myths clinicians have about research and her opportunity to be a part of the Master of Clinical Investigation (MCI) Programme.
Potential of Fetal Gene Therapy to Prevent Lethal Neurodegenerative Disease
A new study led by UCL, KK Women's and Children's Hospital (KKH) and National University Health System in Singapore have found that fetal gene therapy in mice can prevent a fatal neurodegenerative condition known as Gaucher disease, an irreversible, inherited genetic metabolic disorder which could lead to bone disease, seizure and brain damage. Given the promising results shown in mice, the Singapore team performed the test in non-human primates (NHP) at the early stages of pregnancy.
Better Ways to Treat Diabetic Eye Disease
Dr Gavin Tan, Consultant, Surgical Retina Department from the Singapore National Eye Centre (SNEC), shares on studies that have shown the oral drug, Finofibrate, is more effective in reducing retinal swelling for those suffering from diabetic retinopathy and/or macular oedema. By injecting the drug into the eye, the progression of diabetic retinopathy is reduced by at least 50% and the need for laser treatment by 30%.
Ground-breaking Discovery on Y90-RE Radiation Therapy by Singapore Team
A multidisciplinary team of researchers from National Cancer Centre Singapore (NCCS), Translational Immunology Institute (TII) and Singapore General Hospital (SGH) have discovered ground-breaking translational research that Yttrium-90 radioembolisation (Y90-RE), a form of radiation therapy increases anti-cancer immunity and improves tumour response in liver cancer patients. The team also reported the conclusion of a six-year long, 11-country Asia-Pacific phase-III clinical trial led by NCCS.
Enhancing cancer Genetics Testing for Asian Women
National Cancer Centre Singapore (NCCS) and genomic medicine company Lucence Diagnostics will collaborate on a three-year study involving 300 patients to expland clinical database that classifies breast and gynaecological cancer mutations in Asian women across all ethnicities. This clinical database will be the first to focus on the Asian populations to improve genetic testing servies to provide more accurate diagnosis and enhance treatment selection.
NPC, also known as nasopharynx cancer, is the 7th most frequent cancer in males in Singapore. Scientists from National Cancer Centre Singapore (NCCS), in collaboration with Sun Yat-Sen University Cancer Centre (SYSUCC), have developed a first-ever validated clinical tool that helps clinicians identify relapse patients with aggressive NPC resistant to a repeat course of radiotherapy. "..Our prognostic model can also be used as a patient stratification or selection tool in future clinical trials for patients with locally recurrent NPC," Dr Tan Sze Huey, co-investigator and principal biostatistician at NCCS.