SingHealth Tissue Repository (STR) facilitates the conduct of basic, translational and clinical research at SingHealth and Duke-NUS Graduate Medical School. It is the largest research tissue repository in Singapore.

Headed by a pathologist, STR is guided by the SingHealth Tissue Repository Committee, which comprises clinicians practising in major hospitals in Singapore, research scientists as well as lawyers and the Chairman of the Centralised Institutional Review Board, on development and implementation of biospecimen banking policies and guidelines. The committee also works with STR to review and approve requests to collect and access specimens.

STR aims to:
  1. Provide a well-managed tissue repository for all researchers in SingHealth and Singapore by focusing on data security, quality assurance and ethical standards
  2. Ensure proper harvesting, processing and storage of tissues and biospecimens in accordance with national guidelines and international best practices
  3. Encourage collaboration and synergies in research efforts by providing a platform for researchers to share resources and experiences
  4. Provide tissue-based research services and engage in R&D for tissue preservation techniques and research resource management

In line with SingHealth's strategy to promote collaborations for medical advancement, STR hopes to support collaboration between SingHealth principal investigators and international researchers by providing high quality, internationally-accredited, tissue-based research services.

To view the brochure of STR, please click here.

For a list of SingHealth Core Platforms Equipment, click here.

Services

STR offers researchers and their collaborators two types of services:

Core tissue research services

SingHealth research partners can access tissue-related research services, such as provision of cryostat sections, tissue processing, histochemical stains, immunohistochemistry, laser microdissection, interphase FISH and immunoFISH assays to validate biomarkers on tissues, construction of tissue microarray (TMA), and provision of thick tissue sections for DNA/RNA integrity assessment. Click here for enquiries on Core Tissue Research Services.

Biobanking services

STR’s biobank supports both scheduled and unscheduled collections. Serving as a ‘hostelling service’ for researchers who require a facility to process and store bio-resources for the duration of their projects, a scheduled collection includes harvesting of tissue and/or processing blood samples.

An unscheduled collection involves regularly harvesting tissues, mainly malignancies, from consenting patients who undergo surgery, regardless of whether there is an ongoing study. These samples go into STR’s tissue bank. 

For charges on Biobanking services, please email STR at tissue.repository@singhealth.com.sg 

 

 

 

 

 

 

  
 
Application process for request of tissue samples
 
Step 1: Enquiry
Email us at  

tissue.repository@singhealth.com.sg

to check the availability of the tissue material you required
 
 
Step 2: Application
Submit a copy of Request to Use of Material form
together with a copy of approval letter
by Centralised Instiutional Review Board (CIRB)
 
 
Step 3: Review by the STR Committee
This normally takes about 14 working days
 
 
 
 
Rejection
You may reapply with a revised proposal that addresses the reviewers' concerns. These usually relate to: insufficient justification for number of samples requested; or lack of justification for the types of samples requested
Approval & start of project
 
 
We’ll arrange a date for you to collect the tissue material from us and invoice you for the withdrawal
 
    
 
 
 
 
Application process for scheduled collections
 
Step 1: Enquiry
Send your project abstract together with the type and number of biospecimens requested to
  tissue.repository@singhealth.com.sg
after which we will arrange a meeting to discuss your project further
 
 
Step 2: Application
Submit a copy of Application to Use the Services of the SingHealthTissue Repository form together with a copy of the Centralised Instiutional Review Board (CIRB) approval letter
 
 
Step 3: Review by the STR Committee
This normally takes about 14 working days
 
 
 
 
Rejection
You may reapply with a revised proposal that addresses the reviewers' concerns. These usually relate to: insufficient justification for number of samples requested; or lack of justification for the types of samples requested
Approval & start of project
 
 
We will go ahead with the sample collection as specified in the protocol and invoice you for the storage and processing
 
  
 
 
 
Contributing tissues to STR's tissue bank
 
Individual clinicians or departments can contribute tissues to STR. Simply submit the completed Request to Initiate New Collection form to any STR staff or directly to Elsie Kok, STR Senior Medical Technologist. Once the agreement is set up, STR staff will approach your patients before surgery to obtain consent and harvest tissues after in the operating theatre.
 
STR encourages PIs who request contributed tissues to collaborate with the contributing clinicians or departments and offer authorship on publications resulting from this research.