Abstract

Monitoring of the epigenetic mechanisms implicated in the regulation of gene activities offers distinct approach to detection of the key signature gene deregulations associated with the onset and progressions of various diseases. Epigenetic markers range from post-translational modifications of core histone proteins and methylated cytosine residues in DNA to regulatory non-coding RNAs and chromosome conformation signatures. Here we will present multiple independent evidence for the diagnostic value of chromosome conformation signatures and the use of the EpiSwitchTM technology in diagnostic applications for breast, prostate and skin cancers.