Our lab is studying the chromatin and epigenetic mechanisms underlying X-chromosome specific gene regulation using Drosophila dosage compensation as a model system. Dosage compensation mechanisms regulate the expression of X-linked genes. In Drosophila this process leads to the transcriptional upregulation of the single male X chromosome and is regulated by an RNA-protein containing male specific lethal (MSL) complex. The MSL complex localizes on hundreds of sites on the male X chromosome and is involved in hyperacetylation of histone H4 at lysine 16 by MOF, histone acetyltransferase. We will present our progress on our efforts to study the MSL complex using multidisciplinary approaches.

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